SEMAGLUTIDE VS TIRZEPATIDE
SEMAGLUTIDE VS TIRZEPATIDE
Complete comparison of the two most effective weight loss peptides. Mechanisms, results, side effects, and which one produces better weight loss for your goals.
Complete comparison of the two most effective weight loss peptides. Mechanisms, results, side effects, and which one produces better weight loss for your goals.
ESSENTIALS
The key differences between semaglutide and tirzepatide
The key differences between semaglutide and tirzepatide
Features
Semaglutide
Tirzepatide
Best For
First-time users, steady loss
Maximum weight loss, and faster
Average weight loss
15-20% body weight
20-25% body weight
Weekly dose
1mg - 2.4mg
5mg - 15mg
Time to results
4-8 weeks
2-6 weeks
Side effects
Moderate
Slightly higher
Monthly cost
$150-250
$250-400
Features
Semaglutide
Tirzepatide
Best For
First-time users, steady loss
Maximum weight loss, and faster
Average weight loss
15-20% body weight
20-25% body weight
Weekly dose
1mg - 2.4mg
5mg - 15mg
Time to results
4-8 weeks
2-6 weeks
Side effects
Moderate
Slightly higher
Monthly cost
$150-250
$250-400
THE BASICS
What each peptide is and how it works
What each peptide is and how it works
Semaglutide
Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics a natural hormone that regulates appetite and blood sugar. Originally developed for type 2 diabetes, it's now widely used for weight loss. Works by reducing hunger and slowing stomach emptying.
Activating GLP-1 receptors in the brain
Activating GLP-1 receptors in the brain
Suppressing appetite at the hypothalamus
Promoting new blood vessel formation
Slowing gastric emptying (food stays longer)
Slowing gastric emptying
Improving insulin sensitivity
Improving insulin sensitivity
Reducing food noise and cravings
Reducing food noise and cravings
Lowering blood sugar levels
Lowering blood sugar levels
Tirzepatide
Tirzepatide is a dual GIP/GLP-1 receptor agonist. It activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors. The dual mechanism produces stronger weight loss than semaglutide alone. Works systemically for appetite, metabolism, and insulin sensitivity.
Activating both GLP-1 and GIP receptors
Activating both GLP-1 and GIP receptors
Stronger appetite suppression than semaglutide
Promoting new blood vessel formation
Enhanced insulin secretion from GIP
Enhanced insulin secretion from GIP
Greater improvement in insulin sensitivity
Greater improvement in insulin sensitivity
More significant metabolic benefits
More significant metabolic benefits
Faster gastric emptying than semaglutide
Faster gastric emptying than semaglutide
COMPARISON
Complete feature comparison
Complete feature comparison
Every aspect compared side by side, weight loss, speed, side effects, and more
Every aspect compared side by side, weight loss, speed, side effects, and more
Category
Semaglutide
Tirzepatide
Weight loss (12 weeks)
10-15 lbs
15-22 lbs
Weight loss (52 weeks)
15-20% body weight
20-25% body weight
Speed to results
Moderate (4-8 weeks)
Faster (2-6 weeks)
Appetite suppression
Strong
Very strong
Nausea risk
20-30% of users
25-35% of users
Injection frequency
Once weekly
Once weekly
Titration period
8 weeks
8-12 weeks
Maintenance dose
1-2.4mg weekly
10-15mg weekly
Blood sugar control
Excellent
Superior
A1C reduction
1.5-2%
2-2.5%
Cardiovascular benefits
Proven
Promising
FDA approval
Yes (obesity & diabetes)
Yes (diabetes)
Brand names
Ozempic, Wegovy
Mounjaro, Zepbound
Category
Semaglutide
Tirzepatide
Weight loss (12 weeks)
10-15 lbs
15-22 lbs
Weight loss (52 weeks)
15-20% body weight
20-25% body weight
Speed to results
Moderate (4-8 weeks)
Faster (2-6 weeks)
Appetite suppression
Strong
Very strong
Nausea risk
20-30% of users
25-35% of users
Injection frequency
Once weekly
Once weekly
Titration period
8 weeks
8-12 weeks
Maintenance dose
1-2.4mg weekly
10-15mg weekly
Blood sugar control
Excellent
Superior
A1C reduction
1.5-2%
2-2.5%
Cardiovascular benefits
Proven
Promising
FDA approval
Yes (obesity & diabetes)
Yes (diabetes)
Brand names
Ozempic, Wegovy
Mounjaro, Zepbound
Category
Semaglutide
Tirzepatide
Weight loss (12 weeks)
10-15 lbs
15-22 lbs
Weight loss (52 weeks)
15-20% body weight
20-25% body weight
Speed to results
Moderate (4-8 weeks)
Faster (2-6 weeks)
Appetite suppression
Strong
Very strong
Nausea risk
20-30% of users
25-35% of users
Injection frequency
Once weekly
Once weekly
Titration period
8 weeks
8-12 weeks
Maintenance dose
1-2.4mg weekly
10-15mg weekly
Blood sugar control
Excellent
Superior
A1C reduction
1.5-2%
2-2.5%
Cardiovascular benefits
Proven
Promising
FDA approval
Yes (obesity & diabetes)
Yes (diabetes)
Brand names
Ozempic, Wegovy
Mounjaro, Zepbound
CHOOSE YOUR PEPTIDE
Which peptide for your situation
Which peptide for your situation
Choose the right GLP-1 peptide based on your weight loss goals and tolerance
Choose the right GLP-1 peptide based on your weight loss goals and tolerance
Choose Semaglutide if you:
Choose Semaglutide if you:
Are new to GLP-1 medications
Are new to GLP-1 medications
Want proven long-term safety data
Want proven long-term safety data
Need cardiovascular benefits
Need cardiovascular benefits
Prefer lower side effect risk
Prefer lower side effect risk
Have type 2 diabetes
Have type 2 diabetes
Want predictable steady weight loss
Want predictable steady weight loss
Are sensitive to medications
Are sensitive to medications
Need 15-20% weight loss
Need 15-20% weight loss
Choose Tirzepatide if you:
Choose Tirzepatide if you:
Want maximum weight loss results
Want maximum weight loss results
Need to lose 50+ pounds
Need to lose 50+ pounds
Plateaued on semaglutide
Want faster initial results
Want faster initial results
Have significant insulin resistance
Have significant insulin resistance
Can handle slightly higher side effects
Can handle slightly higher side effects
Are willing to pay more
Are willing to pay more
Need 20-25%+ weight loss
Need 20-25%+ weight loss
Use both (Sequential) if you:
Use both if you have:
Start with semaglutide
Start with semaglutide
Switch to tirzepatide if results plateau
Switch to tirzepatide if results plateau
Want to minimize side effects initially
Want to minimize side effects initially
Have insurance covering semaglutide first
Have insurance covering semaglutide
Are cautious about medications
Are cautious about medications
Budget requires starting cheaper
Want maximum total weight loss
Want maximum total weight loss
FREE TOOLS
Explore all peptide calculators
Explore all peptide calculators
Tools to optimize every aspect of your peptide protocol
Tools to optimize every aspect of your peptide protocol
Dosage Calculator
Calculate precise dosages, injection volumes, and frequency for all major peptides based on your body weight.
Reconstitution Calculator
Concentration ratios, injection volumes, and IU measurements when mixing peptide powder with bacteriostatic water.
BPC-157 Calculator
Get injury-specific BPC-157 dosing protocols with cycle length recommendations for optimal healing results.
TB-500 Calculator
Calculate loading and maintenance phase protocols for TB-500 based on injury severity and recovery goals.
Dosage Calculator
Calculate precise dosages, injection volumes, and frequency for all major peptides based on your body weight.
Reconstitution Calculator
Concentration ratios, injection volumes, and IU measurements when mixing peptide powder with bacteriostatic water.
BPC-157 Calculator
Get injury-specific BPC-157 dosing protocols with cycle length recommendations for optimal healing results.
TB-500 Calculator
Calculate loading and maintenance phase protocols for TB-500 based on injury severity and recovery goals.
Dosage Calculator
Calculate precise dosages, injection volumes, and frequency for all major peptides based on your body weight.
Reconstitution Calculator
Concentration ratios, injection volumes, and IU measurements when mixing peptide powder with bacteriostatic water.
BPC-157 Calculator
Get injury-specific BPC-157 dosing protocols with cycle length recommendations for optimal healing results.
TB-500 Calculator
Calculate loading and maintenance phase protocols for TB-500 based on injury severity and recovery goals.
FAQ
Frequently asked questions
Frequently asked questions
Everything you need to know about semaglutide, tirzepatide, and using them for weight loss
Everything you need to know about semaglutide, tirzepatide, and using them for weight loss
Which one is better for weight loss?
Tirzepatide produces 20-30% more weight loss than semaglutide on average. If maximum weight loss is your goal and you can tolerate slightly more side effects, tirzepatide is superior. Semaglutide is better if you want proven long-term safety and slightly gentler side effects.
Which one is better for weight loss?
Tirzepatide produces 20-30% more weight loss than semaglutide on average. If maximum weight loss is your goal and you can tolerate slightly more side effects, tirzepatide is superior. Semaglutide is better if you want proven long-term safety and slightly gentler side effects.
Which one is better for weight loss?
Tirzepatide produces 20-30% more weight loss than semaglutide on average. If maximum weight loss is your goal and you can tolerate slightly more side effects, tirzepatide is superior. Semaglutide is better if you want proven long-term safety and slightly gentler side effects.
Can I switch between them?
Can I switch between them?
Can I switch between them?
How much weight will I lose?
How much weight will I lose?
How much weight will I lose?
Do I need a prescription?
Do I need a prescription?
Do I need a prescription?
How long do I need to take them?
How long do I need to take them?
How long do I need to take them?
Why is tirzepatide more effective?
Why is tirzepatide more effective?
Why is tirzepatide more effective?
What are the serious risks?
What are the serious risks?
What are the serious risks?
Ready to optimize your peptide use?
Ready to optimize your peptide use?
Know you're doing it safely, save hundreds on wrong peptides, and finally see the results you've been working for
Know you're doing it safely, save hundreds on wrong peptides, and finally see the results you've been working for